| Bioactivity | CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNMT (IC50 is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models[1]. |
| Formula | C27H30N6O5 |
| Molar Mass | 518.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. San José-Enériz E, et al., Epigenetic-based differentiation therapy for Acute Myeloid Leukemia. Nat Commun. 2024 Jul 2;15(1):5570. |