| Bioactivity | CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 (HY-13704). These effects are mainly due to its inhibition of phosphorylation of VEGFR-2, EGFR and RET tyrosine kinases and their related signaling pathways[1]. |
| Invitro | CLM3 (0-100 μM, 72 h) 显著降低活化内皮细胞和癌细胞中磷酸化 VEGFR-2、磷酸化 EGFR 和磷酸化 RET 的水平[1]。CLM3 (0-100 μM, 72 h) 显著抑制内皮细胞和癌细胞中细胞周期蛋白 D1 基因的表达，降低细胞周期蛋白 D1 蛋白的细胞内浓度[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CLM3 相关抗体: |
| CAS | 1312024-59-1 |
| Formula | C21H21N5 |
| Molar Mass | 343.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bocci G, et al. Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells. Biochem Pharmacol. 2011 Jun 1;81(11):1309-16. |