| Bioactivity | CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319[1]. |
| CAS | 1210501-46-4 |
| Formula | C15H19ClF4N2O |
| Molar Mass | 354.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry |
CL-385319
CAS: 1210501-46-4 F: C15H19ClF4N2O W: 354.77
CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infectio
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