| Bioactivity | CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1]. | |||||||||
| Invitro | CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours; Jurkat cells) treatment displays cytotoxic activity in Jurkat cells[1]. Cell Viability Assay[1] Cell Line: | |||||||||
| Name | CK2/ERK8-IN-1 | |||||||||
| CAS | 1085822-09-8 | |||||||||
| Formula | C11H9Br4N3O2 | |||||||||
| Molar Mass | 534.82 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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CK2/ERK8-IN-1
CAS: 1085822-09-8 F: C11H9Br4N3O2 W: 534.82
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM.
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