| Bioactivity | CIL-102, an apoptosis inducer, is a MMP-2/MMP-9 inhibitor that decreases MMP-2/MMP-9 protein expression and mRNA levels. CIL-102 displays an anti-cancer activity[1]. |
| Invitro | 在人类白血病 K562 细胞中，CIL-102 诱导 JNK 和 p38 MAPK 活化，但降低磷酸化 ERK 水平。CIL-102 诱导的 p38 MAPK/JNK 活化导致蛋白磷酸酶 2A 介导的三四脯氨酸 (TTP) 下调。此外，CIL-102 降低乳腺癌和肝癌细胞中的侵袭和 MMP-2/MMP-9 表达[1]。CIL-102 通过激活 Fas-L、caspase-8 以及诱导 Bid 裂解和细胞色素 c 释放，以时间依赖性方式在 DLD-1 细胞中触发外源性凋亡途径。CIL-102 通过磷酸化 JNK1/2 信号通路介导细胞凋亡和 G2/M 停滞。这导致 NFκB p50、p300 和 CREB 结合蛋白 (CBP) 水平的表达，以及 p21 和 GADD45 的诱导以及 cdc2/cyclin B 的关联降低。总之，CIL-102 通过上调 p21 和 GADD45 表达以及激活 JNK1/2、NFκB p50 和 p300 来诱导结肠癌细胞的细胞周期停滞和凋亡[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CIL-102 相关抗体: |
| CAS | 479077-76-4 |
| Formula | C19H14N2O2 |
| Molar Mass | 302.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu WH, et al. CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability. Int J Biochem Cell Biol. 2012 Dec;44(12):2212-22. [2]. Huang WS, et al. CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PLoS One. 2017 Jan 9;12(1):e0168989. |