| Bioactivity | CIB-1476 is a caspase-1 inhibitor. CIB-1476 can exert lasting anti-inflammatory effects by inhibiting IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis induced by the NLRP3 inflammasome. CIB-1476 can reduce joint swelling in models of arthritis in mice[1]. |
| Formula | C28H28N2O6S |
| Molar Mass | 520.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cao D, et al. Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis. J Med Chem. 2024 Aug 19. |