| Bioactivity | CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein, respectively[1]. |
| Invitro | CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC50<10 nM),MEG-01 (EC50<10 nM) and KU812 (EC50<30 nM) cells and also significantly blocks the phosphorylation of downstream signaling mediators STAT5, CrkL and ErK[1].CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase[1]. |
| Name | CHMFL-ABL-121 |
| CAS | 2270879-07-5 |
| Formula | C30H31F3N6OS |
| Molar Mass | 580.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
CHMFL-ABL-121
CAS: 2270879-07-5 F: C30H31F3N6OS W: 580.67
CHMFL-ABL-121 is a highly potent type II ABL kinase inhibitor with IC50s of 2 nM and 0.2 nM against purified inactive AB
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