CHIKV-IN-5

CAS: 2568903-91-1 F: C23H17N5OS2 W: 443.54

CHIKV-IN-5 (Compound 26) is a CHIKV inhibitor (EC90 = 0.45 μM). CHIKV-IN-5 inhibits CHIKV replication at a late stage i

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Bioactivity	CHIKV-IN-5 (Compound 26) is a CHIKV inhibitor (EC90 = 0.45 μM). CHIKV-IN-5 inhibits CHIKV replication at a late stage in the virus life cycle by blocking structural protein translation. CHIKV-IN-5 has great in vitro mouse microsomal stability. CHIKV-IN-5 reduces footpad swelling and decreases virus dissemination to other tissues in mice infected with CHIKV[1].
Invitro	CHIKV-IN-5 在正常人真皮成纤维细胞中显示出良好的病毒滴度降低效果 (10 μM 浓度时 VTR=8.7 log)，并在体外小鼠微粒体中显示出稳定性 (MLMt1/2 of 74 min)[1]。CHIKV-IN-5 (10 μM，2 h) 阻止 CHIKV 进入 NHDF 细胞后的复制[1]。CHIKV-IN-5 (10 μM，预处理 1 小时) 抑制 CHIKV 感染的 NHDF 细胞中 CHIKV 结构蛋白的合成，但不抑制病毒转录[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CHIKV-IN-5 相关抗体:
In Vivo	CHIKV-IN-5（80 mg/kg，腹腔注射，每天两次，3 天）可减轻 CHIKV 感染小鼠的足垫肿胀，并显著减少病毒向其他组织的扩散[1]。CHIKV-IN-5 (0.5-20 mg/kg，腹腔注射、静脉注射、口服、皮下注射) 在雄性 C57BL/6 小鼠体内显示出良好的代谢稳定性[1]。小鼠中药代动力学 (PK) 分析 (CHIKV-IN-5)parameters
CAS	2568903-91-1
Formula	C23H17N5OS2
Molar Mass	443.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Garzan, et al. 4-Substituted-2-Thiazole Amides as Viral Replication Inhibitors of Alphaviruses. Journal of medicinal chemistry. 2024, 67(23), 20858–20878.

(-)-(S)-Cibenzoline-d4