| Bioactivity | CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability(CC50 > 100 µM). Prophylactic effect[1]. |
| Invitro | CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 µM; 24 hours) inhibits the Chikungunya virus (CHIKV) replication with an EC50 of 1.55 µM and demonstrates low cytotoxicity (CC50=129.6 µM)[1].CHIKV-IN-3 (HeLa CCL2 cells; 20, 40, 80 µM; 24 hours) shows the highest degree of inhibition with approximately 3.9-log reduction in viral titre (ca. 99.99% inhibition) at 80 µM[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | CHIKV-IN-3 |
| Formula | C24H30ClNO |
| Molar Mass | 383.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |