CHI3L1-IN-1

CAS: 2982256-78-8 F: C22H27Cl2N3O W: 420.38

CHI3L1-IN-1 (Compound 30) is an inhibitor for Chitinase-3-like protein 1 (CHI3L1) (YKL-40) with IC50 of 50 nM. CHI3L1-IN

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Bioactivity	CHI3L1-IN-1 (Compound 30) is an inhibitor for Chitinase-3-like protein 1 (CHI3L1) (YKL-40) with IC50 of 50 nM. CHI3L1-IN-1 inhibits hERG channel with an IC50 of 2.3 μM[1].
Target	50 nM (CHI3L1), 2.3 μM (hERG)
In Vivo	CHI3L1-IN-1 (3 mg/kg，静脉注射) 在 BALB/c 小鼠中的清除率为 24 mL/min/kg，生物利用度为 18%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2982256-78-8
Formula	C22H27Cl2N3O
Molar Mass	420.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Czestkowski W, et al.,Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1. J Med Chem. 2024 Mar 14;67(5):3959-3985.