| Bioactivity | CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (−22.2±4.8% at 100 μM)[1]. |
| Invitro | CHF5022 剂量在浓度高达 300 μM 时不会抑制 COX-1 和 COX-2[1]。CHF5022 (100 μM) 显著下调了两个 AICD（APP 细胞内结构域）反应基因，而对测试的 NICD（Notch 细胞内结构域）靶基因没有任何影响[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CHF5022 相关抗体: |
| In Vivo | 多次口服后，CHF5022 的吸收呈剂量依赖性，在 Tg2575 幼鼠的大脑中渗透性良好 (≈10%)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 749269-77-0 |
| Formula | C17H12F4O2 |
| Molar Mass | 324.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Imbimbo BP, et al. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res. 2007 Apr;55(4):318-28. |