| Bioactivity | CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research[1]. |
| Invitro | CHBO4 (10-500 µg/mL, 48 小时) 在 Vero 细胞中具有生物安全性[1]。CHBO4 (128.8 µg/mL, 10 分钟) 能减少 Vero 细胞中 ROS 生成量[1]。 Cell Cytotoxicity Assay[1] Cell Line: |
| Name | CHBO4 |
| CAS | 98991-32-3 |
| Formula | C15H10BrFO |
| Molar Mass | 305.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Thomas Parambi DG, et al. Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: Synthesis, biochemistry, and molecular dynamics study. Comput Biol Chem. 2023 Aug;105:107899. |