| Bioactivity | CHAPSO is a zwitterionic detergent that is thermally stable. CHAPSO is able to broaden the particle orientation distribution, enabling single-particle cryo-electron microscopy (cryo-EM) to produce isotropically uniform maps. CHAPSO can eliminate the directional bias of bacterial transcription complexes and help determine the structure of bacterial transcription complexes under cryo-electron microscopy[1][2]. |
| CAS | 82473-24-3 |
| Formula | C32H58N2O8S |
| Molar Mass | 630.88 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Li M, et al. Morphological characterization of DMPC/CHAPSO bicellar mixtures: a combined SANS and NMR study. Langmuir. 2013 Dec 23;29(51):15943-57. [2]. Chen J, et al. Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO. J Struct Biol X. 2019 Jan-Mar;1:100005. |