| Bioactivity | CFTR potentiator 1 (I1421) is a potent CFTR potentiator with an EC50 value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR[1]. |
| In Vivo | CFTR potentiator 1 (I1421) 在雄性C57BL/6小鼠中的药代动力学参数[1]。1.19 Route |
| Formula | C18H18N4O3 |
| Molar Mass | 338.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fangyu Liu, et al. Structure-based discovery of CFTR potentiators and inhibitors. Cell. 2024 May 23:S0092-8674(24)00472-0. |