| Bioactivity | CFTR corrector 12 (compound 17C) is a bithiazole derivative, serving as CFTR corrector. CFTR corrector 12 has the ability to correct some folding defective mutants of the channel responsible for the control of chloride transport across the plasma membrane. CFTR corrector 12 recovers the α-sarcoglycan (α-SG) content in mutant cells[1]. |
| Invitro | CFTR corrector 12 (compound 17C) (15 μM; 72 h) 能够恢复 L31P/V247M α-SG 突变细胞中 α-肌聚糖含量[1]。 0 --> CFTR corrector 12 相关抗体: |
| Name | CFTR corrector 12 |
| CAS | 958941-60-1 |
| Formula | C19H21ClN4O2S2 |
| Molar Mass | 436.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ribaudo G, et al. Synthesis and Evaluation of Bithiazole Derivatives As Potential α-Sarcoglycan Correctors. ACS Med Chem Lett. 2023 Jul 28;14(8):1049-1053. |
CFTR corrector 12
CAS: 958941-60-1 F: C19H21ClN4O2S2 W: 436.98
CFTR corrector 12 (compound 17C) is a bithiazole derivative, serving as CFTR corrector. CFTR corrector 12 has the abilit
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