| Bioactivity | CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease[1]. |
| CAS | 208840-22-6 |
| Formula | C33H41N5O6 |
| Molar Mass | 603.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shapiro L, et al. Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1. FASEB J. 2001 Jan;15(1):115-122. |