| Bioactivity | CDK-IN-14 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. CDK-IN-14 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases[1]. |
| Target | IC50: 460 nM (Cyclin-dependent kinase-like 2 (CDKL2)) |
| Invitro | CDK-IN-14 (0-4 μM, 1 小时) 通过抑制 CDKL2，干扰了大鼠初级神经元中 CDKL2 介导的下游信号传导，对 CDKL2 活性具有抑制作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CDKL2-IN-1 相关抗体: Western Blot Analysis[1] Cell Line: |
| CAS | 2471972-15-1 |
| Formula | C22H26N4O3S |
| Molar Mass | 426.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bashore F M, et al. Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2[J]. bioRxiv, 2024. |
CDKL2-IN-1
CAS: 2471972-15-1 F: C22H26N4O3S W: 426.53
CDK-IN-14 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of
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