| Bioactivity | PROTAC CDK9/CycT1 Degrader-1 (compounds 10) is a potent inhibitor of CDK9. PROTAC CDK9/CycT1 Degrader-1 can be used as a PROTAC target protein ligand for PROTAC synthesis. PROTAC CDK9/CycT1 Degrader-1 shows strong anti-proliferative activity in solid tumors[1]. |
| Invitro | CDK9-IN-28 在 U-2932 细胞中表现出明显的 CDK9 降解，在肿瘤中具有明显的抗增殖活性[1]。 0 --> CDK9-IN-28 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | CDK9-IN-28 (5 mg/kg，腹腔注射，每天一次持续15天)在 MV4-11 肿瘤裸鼠模型中抑制了肿瘤生长[1]。CDK9-IN-28 (1 mg/kg，静脉注射，5 mg/kg，腹腔注射)在 ICR (CD-1) 小鼠模型中显示出可接受的半衰期(T1/2:4.66h)和中等的生物利用度(F=43.1%)。 Animal Model: |
| Name | CDK9-IN-28 |
| Formula | C32H40N4O6S2 |
| Molar Mass | 640.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zeng Y, et al. Degradation of Cyclin-Dependent Kinase 9/Cyclin T1 by Optimized Microtubule-Associated Protein 1 Light Chain 3 Beta-Recruiting Coumarin Analogs. J Med Chem. 2023 Sep 6. |