| Bioactivity | CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively.IC50 Value: 10 nM (CDK4/Cyclin D1) [1]Target: CDK4CDK4/6 inhibitor imposed a G1 block on cells at 0.37μM in the CDK4 Cellular Assays. CDK4/6 inhibitor exhibited the most sustained G1 arrest among five compounds and were tested further against a selection of serine-threonine and tyrosine kinases and proved to be selective for CDK4/6 over 35 other kinases [1]. |
| CAS | 1256963-02-6 |
| Formula | C22H29ClN8 |
| Molar Mass | 440.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cho YS, et al. 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem. 2010 Nov 25;53(22):7938-57. |
CDK4-IN-1
CAS: 1256963-02-6 F: C22H29ClN8 W: 440.97
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cycli
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.