| Bioactivity | CDK2/MDM2-IN-1 (III-13) is a dual inhibitor of CDK2/MDM2 with an IC50 value of 2.60 nM for CDK2. CDK2/MDM2-IN-1 has antitumor activity[1]. |
| Invitro | CDK2/MDM2-IN-1 (100, 200 nM, 4 h) 通过 CDK2/p-Rb 和 MDM2/p53 途径抑制肿瘤细胞的增殖[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CDK2/MDM2-IN-1 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | CDK2/MDM2-IN-1 (25, 50 mg/kg, 腹腔注射, 连续 14 天) 能显著抑制小鼠结肠肿瘤细胞的增殖，且不影响小鼠体重[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C26H33N5O4 |
| Molar Mass | 479.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu Z, et al. Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53. Molecules. 2024 Feb 4;29(3):725. |