CDK2-IN-28_product_DataBase

Bioactivity	CDK2-IN-28 (compound 22) is a CDK2 inhibitor with good selectivity and cellular effects against other CDKs. CDK2-IN-28 has anti-proliferative effects on MKN1 cells (EC50: 0.31 μM),[10][1].
Invitro	CDK2-IN-28 (37 nM-3 μM; 24 h) 在 MKN1 细胞中显著下调 Rb 在 Ser807/811 和 Ser780 位置磷酸化的水平[1]。CDK2-IN-28 (333.3 nM; 24 h) 在 MKN1 细胞中引起的 CDK2 抑制，造成了细胞周期在 G2/M 期阻滞[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CDK2-IN-28 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	CDK2-IN-28（10 mg/kg；口服；单剂量）在小鼠中具有较差的血浆暴露，CDK2-IN-28（1 mg/kg；静脉注射；单剂量）在小鼠 PK 测定中也显示出高血浆清除率（159-236 mL/min/kg)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	3025006-64-5
Formula	C25H35N7O3S
Molar Mass	513.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Niu P, et al. Discovery of novel macrocyclic derivatives as potent and selective cyclin-dependent kinase 2 inhibitors. Bioorg Med Chem. 2024 Apr 15;104:117711.

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