CDK1/2/4-IN-1_product_DataBase

Bioactivity	CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
Invitro	CDK1/2/4-IN-1 (compound 3a) (0.01-100 µM; 24 hours) has antitumor activity in cancer cell lines[1].CDK1/2/4-IN-1 (compound 3a) (1.39 µM; 24 hours) induces apoptosis and arrests cell cycle at G2/M phase in A549 cells[1]. CDK1/2/4-IN-1 (compound 3a) (1.39 µM; A549 cells) induces up-regulation of the expression of Bax, caspases-3 and p53, and increases the ratio of Bcl-2[1]. Cell Cytotoxicity Assay[1] Cell Line:
Name	CDK1/2/4-IN-1
CAS	2414633-49-9
Formula	C15H16N2O2S
Molar Mass	288.36
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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