CDDO-2P-Im_product_DataBase

Bioactivity

CDDO-2P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-2P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model[1].

Invitro

CDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM[1].CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC50 of 5.8 nM[1]. Apoptosis Analysis[1] Cell Line:

In Vivo

CDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies[1].CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo[1].CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice[1]. Animal Model:

Name

CDDO-2P-Im

CAS

1883650-96-1

Formula

C39H46N4O3

Molar Mass

618.81

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Cao M , et al. Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention. Pharmacol Res. 2015 Oct;100:135-47.

PeptideDB

CDDO-2P-Im

CAS: 1883650-96-1 F: C39H46N4O3 W: 618.81