| Bioactivity | CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology[1]. | |||||||||
| Target | CD73 | |||||||||
| Invitro | CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73; IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10 000 nM) against CD39, A2aR, and NTPDase2, 3, and 8[1]. | |||||||||
| Name | CD73-IN-4 | |||||||||
| CAS | 2216764-29-1 | |||||||||
| Formula | C16H23ClN5O7P | |||||||||
| Molar Mass | 463.81 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5. |
CD73-IN-4
CAS: 2216764-29-1 F: C16H23ClN5O7P W: 463.81
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73
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