CD38 inhibitor 1_product_DataBase

CAS: 1700637-55-3 F: C22H27N3O3S W: 413.53

CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC50s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38.

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC50s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38[1].

Target

IC50: 7.3 nM (hCD38), 1.9 nM (mouse CD38)Ki: 0.3 nM (WT hCD38)

In Vivo

CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle[1]. Animal Model:

Name

CD38 inhibitor 1

CAS

1700637-55-3

Formula

C22H27N3O3S

Molar Mass

413.53

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Haffner CD, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58(8):3548-71.

PeptideDB

CD38 inhibitor 1

CAS: 1700637-55-3 F: C22H27N3O3S W: 413.53