CD147 degrader 1_product_DataBase

Bioactivity	CD147 degrader 1 is a PROTAC targets CD147 with an DC50 value of 6.72 µM. CD147 degrader 1 inhibits cell proliferation, migration and invasion. CD147 degrader 1 decreases the expression of CD147, MMP9, and p-STAT3 protein. CD147 degrader 1 shows anti-cancer acyivity[1].
Invitro	CD147 degrader 1 (compound 6a) (2.5, 10 µM; 0, 24, 48 h) 抑制 Sk-Mel-28 细胞的迁移和侵袭[1]。CD147 degrader 1 (0, 2.5, 5, 10 µM) 以剂量依赖性方式降低 CD147、MMP9 和 p-STAT3 蛋白的表达[1]。 Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	CD147 degrader 1 (20 mg/kg；腹腔注射；每两天一次，持续 17 天) 在小鼠体内显示出抗癌活性[1]。 Animal Model:
Name	CD147 degrader 1
CAS	2416740-37-7
Formula	C38H42N4O11
Molar Mass	730.76
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhou Z, et al. Targeted degradation of CD147 proteins in melanoma. Bioorg Chem. 2020 Dec;105:104453.

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