| Bioactivity | CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity[1]. |
| Invitro | CCTA-1523 (0-1000 µM；72 小时) 对 H460、H460/MX20、HEK293/pcDNA3.1、HEK/R482、HEK/R482G 和 HEK/R482T 细胞具有细胞毒性[1]。 |
| In Vivo | CCTA-1523 (75 mg/kg；口服；q3d x 6) 与阿霉素 (HY-15142A) (1.8 mg/kg，腹腔注射，q3d X 6) 联合使用可抑制肿瘤生长并延长小鼠的生存时间[1]。 Animal Model: |
| Name | CCTA-1523 |
| CAS | 1616271-41-0 |
| Formula | C16H15Cl2NO3 |
| Molar Mass | 340.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Patel A,et al. Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport. Pharmacol Res. 2017 Jul;121:184-193. |
CCTA-1523
CAS: 1616271-41-0 F: C16H15Cl2NO3 W: 340.20
CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523
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