| Bioactivity | CCT241161 is an orally active pan-RAF inhibitor with IC50s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF and BRAF, respectively. CCT241161 shows good activity to in BRAF and NRAS mutant melanomas. CCT241161 also exhibits anticancer cell proliferative activity[1]. |
| Invitro | CCT241161 (1, 3, 10, 30, 100 nM; 24 h) inhibits MEK and ERK in WM266.4 cells[1].CCT241161 (1, 10, 100 nM and 1, 10, 100 µM) inhibits BRAFV600E in Ba/F3 cells[1].CCT241161 (0.5 µM; 20 days) inhibits A375 cell but not cause drug resistance[1].CCT241161 (1 µM , 4 h) inhibits BRAF-inhibitor-resistant melanoma cells[1].CCT241161 (0.1, 0.3, 1, 3, 10 µM; 24 h) inhibits MEK in NRAS mutant cells[1].CCT241161 (0.1, 1, 10, 100 µM) shows anti-proliferative activity in D04 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | CCT241161 |
| CAS | 1163719-91-2 |
| Formula | C28H27N7O3S |
| Molar Mass | 541.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
CCT241161
CAS: 1163719-91-2 F: C28H27N7O3S W: 541.62
CCT241161 is an orally active pan-RAF inhibitor with IC50s of 3, 6, 10, 15 and 30 nM for LCK, CRAF, SRC, V600E-BRAF and
Data collection：peptidedb@qq.com
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