| Bioactivity | CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the treatment of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220)[1]. |
| Name | CCR8 antagonist 2 |
| CAS | 2756350-98-6 |
| Formula | C23H30ClN3O3S |
| Molar Mass | 464.02 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Guohuang FAN, et al. Methods and compositions for targeting tregs using ccr8 inhibitors. |
CCR8 antagonist 2
CAS: 2756350-98-6 F: C23H30ClN3O3S W: 464.02
CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Tr
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