| Bioactivity | CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. | ||||||||||||
| Invitro | CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration[1]. | ||||||||||||
| Name | CCR6 inhibitor 1 | ||||||||||||
| CAS | 2437547-04-9 | ||||||||||||
| Formula | C24H23F3N4O3S | ||||||||||||
| Molar Mass | 504.52 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072. |
CCR6 inhibitor 1
CAS: 2437547-04-9 F: C24H23F3N4O3S W: 504.52
CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much m
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.