CCR5 antagonist 2_product_DataBase

Bioactivity	CCR5 antagonist 2 (Compound 25) is a CCR5 antagonist with an IC50 of 8.34 nM. CCR5 antagonist 2 shows broad-spectrum anti-HIV-1 activities[1].
Invitro	CCR5 antagonist 2 (Compound 25) (48 h) 在 TZM-bl 细胞中表现出优异的 HIV-1 抑制活性，EC50 为 0.011 ± 0.002 μM[1]。CCR5 antagonist 2 (48 h) 对 TZM-bl 细胞中亲 CCR5 整合酶抑制剂耐药株 HIV-1YU-2(G140S/Q148H) 具有抗病毒活性，EC50 为 4.34 ± 1.61 nM[1]。CCR5 antagonist 2 对 HIV-1 菌株 KIZ001、YU-2、KIZ006、SF162 和 Ba-L 有抑制作用，EC50 分别为 7.82、8.73、12.61、15.99 和 16.93 nM[1]。
In Vivo	PK Properties of CCR5 antagonist 2 (Compound 25) in SD Rats[1] compd
Name	CCR5 antagonist 2
CAS	1800570-93-7
Formula	C32H45F2N5O2S
Molar Mass	601.79
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xie X, et al. Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability. J Med Chem. 2022 Dec 22;65(24):16526-16540.

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