| Bioactivity | CCR4 antagonist 4 (compound 22) is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM). CCR4 antagonist 4 can be used for allergic inflammation research[1]. |
| Name | CCR4 antagonist 4 |
| CAS | 668980-17-4 |
| Formula | C24H27Cl2N7O |
| Molar Mass | 500.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Purandare AV, et al. Core exploration in optimization of chemokine receptor CCR4 antagonists. Bioorg Med Chem Lett. 2007 Feb 1;17(3):679-82. |
CCR4 antagonist 4
CAS: 668980-17-4 F: C24H27Cl2N7O W: 500.42
CCR4 antagonist 4 (compound 22) is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50
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