| Bioactivity | CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues.CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1]. |
| Target | IC50: 40 nM (Ca2+flux); 70 nM (CTX) (CCR4 antagonist 2) |
| Name | CCR4 antagonist 2 |
| CAS | 2206788-99-8 |
| Formula | C26H28Cl2N6O |
| Molar Mass | 511.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment. J Med Chem. 2019 Jul 11;62(13):6190-6213. |
CCR4 antagonist 2
CAS: 2206788-99-8 F: C26H28Cl2N6O W: 511.45
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine recept
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