| Bioactivity | CCR1 antagonist 12 (Compound 12) is an antagonist for CCR1 with IC50 of 3 nM for human CCR1. CCR1 antagonist 12 inhibits CCL3-induced transwell chemotaxis with an IC50 of 0.009 µM. CCR1 antagonist 12 exhibits good pharmacokinetic characters in rats model[1]. |
| CAS | 921208-19-7 |
| Formula | C25H27ClFN3O4 |
| Molar Mass | 487.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Revesz L, et al. Bridged piperazines and piperidines as CCR1 antagonists with oral activity in models of arthritis and multiple sclerosis[J]. Letters in Drug Design & Discovery, 2006, 3(10): 689-694. |
CCR1 antagonist 12
CAS: 921208-19-7 F: C25H27ClFN3O4 W: 487.95
CCR1 antagonist 12 (Compound 12) is an antagonist for CCR1 with IC50 of 3 nM for human CCR1. CCR1 antagonist 12 inhibits
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