CCR1 antagonist 11 hydrochloride_product_DataBase

Bioactivity	CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases[1].
Target	IC50: 0.03 μM (hCCR1)，0.58 μM (mCCR1), 0.32 μM (rCCR1).
Invitro	CCR1 antagonist 11 hydrochloride(A1B1) inhibits MIP-1α-induced Ca2+ mobilization in THP-1 cells with the IC50 value of 1 nM[1].
In Vivo	The pharmacokinetic parameters of CCR1 antagonist 11 hydrochloride(A1B1) in rat Parameters
Name	CCR1 antagonist 11 hydrochloride
Formula	C23H26Cl2FN3O2
Molar Mass	466.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Laszlo Revesz, et al. Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5160-4.

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