| Bioactivity | CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar Kd value. CC-90002 can be used for the research of hematologic malignancies and solid tumors[1][2]. |
| Invitro | CC-90002 has a high affinity for binding to CD47 with a subnanomolar dissociation constant (Kd) value[1]. CC-90002 can block the CD47-SIRPa interaction with IC50 value in the subnanomolar range[1].CC-90002 has inhibitory effect in concentration-dependent in the ALL and AML cell lines[1]. |
| In Vivo | CC-90002 shows significant dose-dependent antitumor activity and significant tumor regression in tumor xenografts models[1]. |
| Name | CC-90002 |
| CAS | 2085844-54-6 |
| Appearance | Liquid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rama Krishna Narla, et al. The humanized anti-CD47 monclonal antibody, CC-90002, has antitumor activity in vitro and in vivo. [2]. Zhongxing Jiang, et al. Targeting CD47 for cancer immunotherapy. J Hematol Oncol. 2021 Oct 30;14(1):180. |