| Bioactivity | CBR Agonist-2 is a CB1 agonist (CB1R; CB1 ligand) with an EC50 and a Ki of 960 nM and 970 nM, respectively. CBR Agonist-2 is a promising tool for investigating the involvement of hCB1R in disorders associated with the endocannabinoid system[1]. |
| Invitro | CBR Agonist-2 (10 nM-1 μM; 24 hours) induces ERK1/2 activation in a dose-dependent manner in CHO cells expressing Gαq16 and hCB1[1]. Western Blot Analysis[1] Cell Line: |
| Name | CBR Agonist-2 |
| Formula | C27H27FN4O |
| Molar Mass | 442.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Diego A Rodríguez-Soacha, et al. Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB 1 R) "Cis-On" Agonist. ACS Chem Neurosci.2022 Jul 26. doi: 10.1021/acschemneuro.2c00160. |