CB7993113_product_DataBase

Bioactivity	CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively[1].
Invitro	当以至少高达 20 μM 的浓度添加到多种人类细胞（包括 HepG2 肝癌细胞、BP1、D3、Hs578T 或 MDA-MB-231 乳腺癌细胞以及原代人诱导多能干细胞）时，CB7993113 不会表现出毒性 [1]。CB7993113 显着降低 ER-/PR-/HER2- 乳腺癌细胞的体外侵袭表型[1]。 0 --> CB7993113 相关抗体:
In Vivo	CB7993113 可有效阻断 50 mg/kg DMBA (HY-W011845) 诱导的急性肝 CYP1A1 诱导和体内骨髓毒性[1]。
Name	CB7993113
CAS	819827-50-4
Formula	C15H10BrNO5
Molar Mass	364.15
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Parks AJ, et al. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol. 2014 Nov;86(5):593-608.

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