| Bioactivity | CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1]. | |||||||||
| Invitro | CB2R/FAAH modulator-3 (compound 27)(10 μM) 在未刺激的单核细胞和巨噬细胞中，可以降低促炎细胞因子 TNFα、IFN-γ、IL-1β 和 IL6 的产生[1]。 | |||||||||
| Name | CB2R/FAAH modulator-3 | |||||||||
| CAS | 2876918-67-9 | |||||||||
| Formula | C22H31NO2 | |||||||||
| Molar Mass | 341.49 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Francesca Intranuovo, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250. |
CB2R/FAAH modulator-3
CAS: 2876918-67-9 F: C22H31NO2 W: 341.49
CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki
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