| Bioactivity | CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1]. |
| Invitro | CB2R/FAAH modulator-2 (compound 26)(10 μM) 在未刺激的单核细胞和巨噬细胞中，可以降低促炎细胞因子 TNFα、IFN-γ、IL-1β 和 IL6 的产生[1]。 |
| Name | CB2R/FAAH modulator-2 |
| CAS | 2876918-68-0 |
| Formula | C24H33NO2 |
| Molar Mass | 367.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Francesca Intranuovo, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250. |
CB2R/FAAH modulator-2
CAS: 2876918-68-0 F: C24H33NO2 W: 367.52
CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki
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