| Bioactivity | CB2R/5-HT1AR agonist 1 (Compound 2o) is an orally active partial agonist of the CB2 receptor (EC50=479.6 nM). CB2R/5-HT1AR agonist 1 is a full agonist of 5-HT1A receptor (EC50=2.7 μM). CB2R/5-HT1AR agonist 1 exhibits anti-anxiety and anti-depressive effects. CB2R/5-HT1AR agonist 1 possesses favorable pharmacokinetic properties[1]. |
| Target | EC50: 479.6 nM (CB2).EC50: 2.7 μM (5-HT1A). |
| Name | CB2R/5-HT1AR agonist 1 |
| CAS | 2821085-76-9 |
| Formula | C24H33NO3 |
| Molar Mass | 383.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang W, et al. Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety. Eur J Med Chem. 2023 Dec 14;265:116048. |