| Bioactivity | CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC50 value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role[1]. |
| Invitro | CB2R agonist 1 (Compound 4) (1 μM 和 10 μM；24 h) 以浓度依赖性方式增加单核细胞和巨噬细胞中 IL-4、IL-10 抗炎细胞因子的产生，减少 TNF-α、IFN-γ、IL-1β、IL-6 促炎性细胞因子的产生[1]。 |
| Name | CB2R agonist 1 |
| CAS | 1817633-49-0 |
| Formula | C22H32N2O |
| Molar Mass | 340.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Graziano G, et al. N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R). Eur J Med Chem. 2023 Feb 15;248:115109. |
CB2R agonist 1
CAS: 1817633-49-0 F: C22H32N2O W: 340.50
CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC50 value of 0.56 µM. CB2R agoni
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