| Bioactivity | CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1]. |
| Invitro | CB2R PAM (100 nM) significantly enhances the ability of CP55940 and 2-AG, but not of AEA, to stimulate [35S]GTPγS binding to CB2Rs[1]. |
| In Vivo | CB2R PAM (1-20 mg/kg; p.o.) displays antinociceptive activity[1]. Animal Model: |
| Name | CB2R PAM |
| CAS | 2244579-87-9 |
| Formula | C21H24BrFN2O2 |
| Molar Mass | 435.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62(1):276-287. |
CB2R PAM
CAS: 2244579-87-9 F: C21H24BrFN2O2 W: 435.33
CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antin
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