CB2 receptor agonist 6_product_DataBase

Bioactivity	CB2 receptor agonist 6 (compound 70) is an agonist of CB2R, with EC50 of 162 nM. The IC50 values of CB2 receptor agonist 6 are 4.83 μM for CB1R and 0.88 μM for CB2R. CB2 receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease[1].
Invitro	CB2 receptor agonist 6 (compound 70) (5 μM, 0/15/30/60 min) 在体外代谢稳定性研究中表现良好[1]。CB2 receptor agonist 6 (5 μM, 0/0.5/1/1.5/2 h) 具有体外激活 CB2R 的活性，抑制人和小鼠的cAMP 表达[1]。CB2 receptor agonist 6 (0.01-10 μM, 90 min) 在体外竞争结合实验中，与 CB1R 和 CB2R 的 Ki 值分别为 8.8 nM 和 0.89 nM，表现出对 CB2R 的选择性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CB2 receptor agonist 6 相关抗体:
In Vivo	CB2 receptor agonist 6 (compound 70) (1/5/10 mg/kg, intraperitoneal injection, predetermined intervals 0.25/0.5/1/2/6/24 h) 可显著逆转东莨菪碱致健忘症小鼠模型的遗忘效果，同时不会影响正常小鼠的空间学习和记忆能力[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C24H19FN2O
Molar Mass	370.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Di Micco S, et al. Novel pyrrole based CB2 agonists: New insights on CB2 receptor role in regulating neurotransmitters' tone. Eur J Med Chem. 2024 Mar 11;269:116298.

PeptideDB

CB2 receptor agonist 6

CAS: F: C24H19FN2O W: 370.42