| Bioactivity | CB10-277 is a Dacarbazine (HY-B0078) analog that mediates alkylation of guanine residues at the O6 position in DNA and subsequently reduces ATase levels in lymphocytes and tumors. CB10-277 is useful in the study of metastatic malignant melanoma[1]. |
| CAS | 7203-91-0 |
| Formula | C9H11N3O2 |
| Molar Mass | 193.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Siow Ming, et al. "In vivo depletion of O 6-alkylguanine-DNA-alkyltransferase in lymphocytes and melanoma of patients treated with CB 10-277, a new DTIC analogue." Cancer chemotherapy and pharmacology 31 (1992): 240-246. |