| Bioactivity | CB-7921220 is an adenylate cyclase inhibitor. | ||||||||||||
| Invitro | CB-7921220 shows a degree of isoform selectivity for adenylate cyclase (AC) 1, but cannot distinguish between AC1 and AC6. CB-7921220 has a more consistent predicted binding position in the two virtual docking screens, and has a binding conformation similar to ATP and P-site inhibitors, which may explain its lack of selectivity between AC1 and AC6[1]. | ||||||||||||
| Name | CB-7921220 | ||||||||||||
| CAS | 115453-99-1 | ||||||||||||
| Formula | C14H12N2O2 | ||||||||||||
| Molar Mass | 240.26 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Brand CS, et al. Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75. |