| Bioactivity | CB-184 is a selective ligand for sigma-2 (σ2), with Ki values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity[1][2]. |
| CAS | 165307-47-1 |
| Formula | C22H21Cl2NO2 |
| Molar Mass | 402.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Carmen Abate, et al. Classes of sigma2 (σ2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity. Curr Pharm Des. 2012;18(7):938-49. [2]. Keith W Crawford, et al. sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells. Eur J Pharmacol. 2002 May 17;443(1-3):207-9. |