| Bioactivity | CB-0821 is a high affinity CCR5 inhibitor with a Ki of 0.04 nM. CB-0821 binds efficiently to the hydrophobic pocket of the CCR5 protein, to inhibit the interactions between viral protein and CCR5, thereby inhibiting viral entry. CB-0821 has the potential for anti-HIV research[1]. |
| Invitro | CB-0821 (10-200 nM) 以剂量依赖性方式抑制外周血单核细胞 (PBMC) 中的 CCR5，同时浓度高达 500 nM 时对 Vero 细胞无毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CB-0821 相关抗体: |
| Formula | C29H41F2N5O |
| Molar Mass | 513.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ashish Kumar. CB-0821, a novel CC chemokine receptor 5 (CCR5) inhibitor with improved binding efficacy proposed as anti-HIV candidate: Computational and in vitro approach. Biotechnol Appl Biochem. 2024 Mar 31. |