| Bioactivity | CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM. |
| Invitro | CAY10595 (compound 71) is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM[1]. |
| In Vivo | Administration of the DP2 antagonist CAY10595 slightly delays the development of CIA. Treatment with CAY10595 reduces IgG2a anti-CII levels without modification of IgG anti-CII levels[2]. |
| Name | CAY10595 |
| CAS | 916047-16-0 |
| Formula | C20H13Cl2FN2O5 |
| Molar Mass | 451.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Crosignani S, et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem. 2008 Apr 10;51(7):2227-43. [2]. Maicas N, et al. Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. Arthritis Rheum. 2012 Jan;64(1):130-40. |