| Bioactivity | CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM[1][2]. |
| Invitro | CAY10581 (100 nM; 24 小时) 消除 IFN-γ 在 MSCs 中的生长抑制[1]。CAY10581 (化合物 36) 在 100 μM 浓度下 24 小时后对 T-REx 细胞活力的影响极小[2]。 Cell Viability Assay[1] Cell Line: |
| Name | CAY10581 |
| CAS | 1018340-07-2 |
| Formula | C22H21NO4 |
| Molar Mass | 363.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sanjeev Kumar, et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. [2]. Siddaraju V Boregowda, et al. A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells. EBioMedicine. 2015 Dec 24;4:62-73. |